Seropositivity of WNV is low compared to the other diseases circulating throughout the area. WNV is a great opportunity for WHO and PAHO to work together within countries of Latin America to collect reliable data and implement preventative measures. Although it does not pose an immediate threat WNV has the potential of endemicity, especially in Latin America that serves as a suitable environment for the many abundant hosts of WNV. Within three years the United States experienced a WNV epidemic that reached neighboring countries including Mexico. It cannot be enough to assume WNV does not affect Latin America but the question should be when. 

In other countries currently experiencing WNV endemics, underreporting or misdiagnosis seem to be the largest complications. Currently vaccination for horses as well as humans is understudy. Once the research is done, by providing equine and human populations with the correct preventative measures should safeguard the country against WNV reaching epidemic levels. A plan should include strategies that find ways to provide rural and marginalized communities with the appropriate resources needed to prepare for any possible endemics. Knowing the importance of avian reservoirs in the transmission of WNV, local governments should prepare avian populations along with their mosquito vector populations. With research on many diseases, even those excluding zoonotic diseases, it is not unknown that diseases within Latin America will continually marginalize the poor communities that lack resources.