Lecture 22 objectives and skills
- Describe features that distinguish bases from nucleophiles.
- Understand/interpret/draw reaction coordinate diagrams to describe SN vs E selectivity.
- Explain substrate, base, solvent, and temperature selectivity trends for all SN and E mechanisms.
- Rationalize reactivity trends for halides and alcohols.
- Predict mechanism and product(s) of a given reaction.
- Combine all known reactions to solve synthesis problems.
Skills
- Critical assessment using abstract concepts
- Outcome predictions
- Comparisons of fine details
- Comparisons of multiple variables
- Building knowledge libraries
