Lecture 21 objectives and skills
- Describe features that distinguish strong bases from weak bases.
- Describe features that distinguish good leaving groups from poor leaving groups.
- Describe features that distinguish polar protic, polar aprotic, and non-polar solvents from each other.
- Understand/interpret/draw reaction coordinate diagrams to describe E1/E2 selectivity.
- Explain substrate, base, solvent, and leaving group selectivity trends for E1 vs E2.
- Rationalize reactivity trends for halides and alcohols.
- Predict the mechanism and product(s) of E reactions.
- Combine all known reactions to solve synthesis problems.
Skills
- Critical assessment using abstract concepts
- Outcome predictions
- Comparisons of fine details
- Comparisons of multiple variables
- Building knowledge libraries
