J. Hector St. Jean de Crevecoeur's "Letters from an American Farmer"

epidemics of diseases deadly to Native Americans decimated populations

Many European immigrants who arrived after the epidemics had already killed massive numbers of American natives assumed that the natives had always been few in number. The scope of the epidemics over the years was enormous, killing millions of people—in excess of 90% of the population in the hardest hit areas—and creating "the greatest human catastrophe in history, far exceeding even the disaster of the Black Death of medieval Europe."

The most devastating disease was smallpox, but other deadly diseases included typhus, measles, influenza, bubonic plague, mumps, yellow fever, and whooping cough. The Americas also had endemic diseases, perhaps including a type of syphilis, which soon became rampant in the Old World. (This transfer of disease between the Old and New Worlds was part of the phenomenon known as the " Columbian Exchange.") The diseases brought to the New World proved to be exceptionally deadly.

The epidemics had very different effects in different parts of the Americas. The most vulnerable groups were those with a relatively small population. Many island based groups were utterly annihilated. 

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